Everything about Polycystic Kidney Disease totally explained
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ICD9 = |
ICDO = |
Image = Polycystic kidneys, gross pathology 20G0027 lores.jpg |
Caption = Polycystic kidneys |
OMIM = 173900 |
MedlinePlus = 000502 |
eMedicineSubj = med |
eMedicineTopic = 1862 |
eMedicine_mult = |
DiseasesDB = 10262 |
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MeshID = D007690 |
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Polycystic kidney disease (
PKD, also known as polycystic kidney syndrome) is a progressive,
genetic disorder of the
kidneys. It occurs in
humans and other
organisms. PKD is characterized by the presence of multiple
cysts (hence, "polycystic") in both
kidneys. The disease can also damage the
liver,
pancreas, and rarely, the
heart and
brain. The two major forms of polycystic kidney disease are distinguished by their patterns of inheritance.
Autosomal dominant polycystic kidney disease (ADPKD) is generally a late-onset disorder characterized by progressive cyst development and bilaterally enlarged kidneys with multiple cysts. Kidney manifestations in this disorder include renal function abnormalities,
hypertension, renal
pain, and renal insufficiency. Approximately 50% of patients with ADPKD have end-stage renal disease (ESRD) by the age of 60. ADPKD is a systemic disease with cysts in other organs such as the
liver (which may lead to
cirrhosis),
seminal vesicles, pancreas, and
arachnoid mater and non-cystic abnormalities such as intracranial
aneurysms and
dolichoectasias, dilatation of the
aortic root and dissection of the
thoracic aorta,
mitral valve prolapse, and abdominal wall hernias.
Initial simian and human
symptoms are
hypertension,
fatigue, and mild to severe back or flank pain and
urinary tract infections. The disease often leads to
chronic renal failure and may result in total loss of kidney function, known as
end stage renal disease (ESRD), which requires some form of
renal replacement therapy (for example
dialysis).
Autosomal recessive polycystic kidney disease (ARPKD) is much rarer than ADPKD and is often fatal in utero or during the first month of life. The signs and symptoms of the condition are usually apparent at birth or in early infancy.
Genetics
The disease exists both in an
autosomal recessive and an
autosomal dominant form.
Autosomal dominant form
The autosomal dominant form, called ADPKD (autosomal dominant PKD or "Adult-onset PKD") is much more common but less severe. In 85% of patients, ADPKD is caused by
mutations in the
gene PKD1 on chromosome 16 (TRPP1); in 15% of patients mutations in
PKD2 (TRPP2) are causative. A third locus
PKD3 is the cause of a very small percentage of cases.
Autosomal recessive form
The recessive form, called ARPKD (autosomal recessive polycystic kidney disease) is the less common variant. Mutations in the
PKHD1 (chromosomal locus 6p12.2) cause ARPKD.
,
Other types
A small number of families with polycystic kidney disease don't have apparent mutations in any of the three known genes. An unidentified gene or genes may also be responsible for this disease. In this case, the disease is designated "PKD3".
Epidemiology
Polycystic kidney disease is the most common life-threatening genetic disease, affecting approximately 7 million people worldwide. Autosomal dominant polycystic kidney disease affects up to 1 in 1000 people, while the autosomal recessive type is estimated to occur in approximately 1 in 20,000 people.
Pathophysiology
Recent studies in fundamental cell biology of cilia/flagella using experimental model organisms like the green algae Chlamydomonas, the round worm Caenorhabditis elegans and the mouse Mus musculus have shed light on how PKD develops in patients. All cilia and flagella are constructed and maintained, including localizing of proteins inserted into ciliary and flagellar membranes, by the process of intraflagellar transport. Environmental sensing and cellular signaling pathways initiated from proteins inserted into ciliary/flagellar membranes are thought to be critical for normal renal cell development and functioning. Membrane proteins which function in developmental and physiological environmental sensing and intracellular signalling are sorted to and localized to the cilia in renal epithelial cells by intraflagellar transport. These epithelial cells line the lumen of the urinary collecting ducts and sense the flow of urine. Failure in flow-sensing signaling results in programmed cell death or apoptosis of these renal epithelial cells producing the characteristic multiple cysts of PKD. PKD may result from mutations of signaling and environmental sensing proteins, or failure in intraflagellar transport. Two PKD genes, PKD1 and PKD2, encode membrane proteins which localize to a non-motile cilium on the renal tube cell. Polycystin-2 encoded by PKD2 gene is a calcium channel which allows extracellular calcium ions to enter the cell. Polycystin-1, encoded by PKD1 gene, is thought to be associated with polycystin-2 protein and regulate its channel activity. The calcium ions are important cellular messengers which, in turn, trigger complicated biochemical pathways which lead to quiescence and differentiation. Malfunctions of polycystin-1 or polycystin-2 proteins, defects in the assembly of the cilium on the renal tube cell, failures in targeting these two proteins to the cilium, and deregulations of calcium signaling all likely cause the occurrence of PKD.
PKD and the "two hit" hypothesis:
The two hit hypothesis (aka Knudson hypothesis ) is often used to explain the manifestation of polycystic kidney disease later in life even though the mutation is present at birth. This term is borrowed from cancer research stating that both copies of the gene present in the genome have to be "silenced" before cancer manifests itself (in Knudson's case the silenced gene was Rb1). In ADPKD the original "hit" is congenital (in either the PKD1 or PKD2 genes) and the subsequent "hit" occurs later in life as the cells grow and divide. The two hit hypothesis as it relates to PKD was originally proposed by Reeders in 1992. Support for this hypothesis comes from the fact that ARPKD patients develop disease at birth, and somatic mutations in the "normal" copy of PKD1 or PKD2 have been found in cyst-lining epithelia
Diagnosis
A definite diagnosis of ADPKD relies on imaging or molecular genetic testing. The sensitivity of testing is nearly 100% for all patients with ADPKD who are age 30 years or older and for younger patients with PKD1 mutations; these criteria are only 67% sensitive for patients with PKD2 mutations who are younger than age 30 years. Large echogenic kidneys without distinct macroscopic cysts in an infant/child at 50% risk for ADPKD are diagnostic. In the absence of a family history of ADPKD, the presence of bilateral renal enlargement and cysts, with or without the presence of hepatic cysts, and the absence of other manifestations suggestive of a different renal cystic disease provide presumptive, but not definite, evidence for the diagnosis.
Molecular genetic testing by linkage analysis or direct mutation screening is available clinically; however, genetic heterogeneity is a significant complication to molecular genetic testing. Sometimes a relatively large number of affected family members need to be tested in order to establish which one of the two possible genes is responsible within each family. The large size and complexity of PKD1 and PKD2 genes, as well as marked allelic heterogeneity, present obstacles to molecular testing by direct DNA analysis. In the research setting, mutation detection rates of 50-75% have been obtained for PKD1 and ~75% for PKD2. Clinical testing of the PKD1 and PKD2 genes by direct sequence analysis is now available, with a detection rate for disease-causing mutations of 50-70%.
Genetic counseling may be helpful for families at risk for polycystic kidney disease.
Treatment
Although a cure for PKD isn't available, treatment can ease the symptoms and prolong life.
Pain: Over-the-counter pain medications, such as paracetamol can relieve pain. For most but not all cases of severe pain, surgery to shrink cysts can relieve pain in the back and flanks. However, surgery provides only temporary relief and usually doesn't slow the disease's progression toward kidney failure.
Urinary tract infections: Patients with PKD tend to have frequent urinary tract infections, which can be treated with antibiotics. Early treatment is important, because infection can spread from the urinary tract to the cysts in the kidneys. Cyst infections are difficult to treat because many antibiotics don't penetrate into the cysts. However, some antibiotics are effective.
High blood pressure: Keeping blood pressure under control can slow the effects of PKD. Lifestyle changes and various medications can lower high blood pressure.
End-stage renal disease: There are two options for replacing kidney functions: dialysis or transplantation. Healthy (non-PKD) kidneys transplanted into PKD patients don't develop cysts.
In cats
Polycystic Kidney Disease (PKD) is also prevalent in Persian, Himalayan, and Exotic Cats.
There are 3 possible genotypes for PKD:
1) N/N (2 copies of the normal allele)
2) N/P Heterozygote (1 normal copy and 1 copy of the PKD mutation)
3) P/P (2 copies of the PKD mutation)
PKD DNA testing is available to identify these genotypes to help cat breeders make more informed decisions about mating patterns.
Resources
The PKD Foundation
is the only non-profit organization worldwide dedicated solely to PKD research.
Parent of two children with ARPKD blog: www.kidneysandeyes.com
Further Information
Get more info on 'Polycystic Kidney Disease'.
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